The Greyhound bus station is not very safe that late at night. 30th Street Station (on JFK and 30th St), which serves the Amtrak, is actually very safe. I've done the Philly to NYC bus trip 10+ times and even at weird hours (like .. 12am or 5am) there are enough people around out by the bus stand at the back that I feel perfectly safe.
Center City is extremely safe, and you can feel comfortable on the streets basically any time of day or night, but if you wander too far north from Fishtown, Center City or too far south from South Philly, you may find yourself in a sticky spot. If you're not familiar with the lay of the land, stick to the most populated areas.
Walking around Philadelphia in the summer time, come along with me, let’s explore downtown Center City
2021. 7. 23. · Vacationers need to know: is Pittsburgh Downtown safe? Mugging is a medium risk, so people should always use extra caution when on the streets, especially at night. Some of the neighborhoods are known for higher rates of crime. Always try to walk on well-lit streets and avoid alleyways, even if it is faster.